Structure of PDB 7jre Chain D Binding Site BS01

Receptor Information
>7jre Chain D (length=139) Species: 42789 (enterovirus D68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FGGVFVGSFKIINYHLATIEERQSAIYVDWQSDVLVTPIAAHGRHQIARC
KCNTGVYYCRHRDKSYPVCFEGPGIQWIEQNEYYPARYQTNVLLAAGPAE
AGDAGGLLVCPHGVIGLLTAGGGGIVAFTDIRNLLWLDT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7jre Chain D Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jre Crystal structure of EV-D68 2A protease C107A mutant
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C53 C55 C113 H115
Binding residue
(residue number reindexed from 1)		C50 C52 C110 H112
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:7jre, PDBe:7jre, PDBj:7jre
PDBsum7jre
PubMed
UniProtQ68T42|POLG_HED68 Genome polyprotein

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