Structure of PDB 7eu7 Chain D Binding Site BS01

Receptor Information
>7eu7 Chain D (length=781) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLI
THVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASM
IMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREF
ISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK
DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDD
WDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT
LHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTL
SLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNT
VPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG
KHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGI
SVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFTIGK
AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM
IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQ
YMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSG
YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNE
KLDIDNMAGVFYMLAAAMALSLITFIWEHLF
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7eu7 Chain D Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7eu7 Structural basis of ketamine action on human NMDA receptors.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H485 L512 T513 R518 G688 Y730 D731
Binding residue
(residue number reindexed from 1)		H452 L479 T480 R485 G635 Y677 D678
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eu7, PDBe:7eu7, PDBj:7eu7
PDBsum7eu7
PubMed34321660
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

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