Structure of PDB 7dxb Chain D Binding Site BS01

Receptor Information
>7dxb Chain D (length=738) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPAFMFNTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQN
ALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPG
FAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVV
HMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAY
LSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDL
CRDSEEVEAILNGDASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLS
GLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAH
AASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEM
LIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFL
AFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISE
GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFF
AFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYD
HKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFAR
SKLWLSYFDDGKTLPPPFSLVPQPTRYQQIMKRLIKRYVLKAQVDKENDE
VNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKL
Ligand information
Ligand ID98R
InChIInChI=1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h15-18,37,40H,3-14,19-36H2,1-2H3/b17-15?,18-16+/t37-/m0/s1
InChIKeyUGRFXJLWUONJDY-NVXOQYPQSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CCCCCCCC=CCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCCC/C=C/CCCCCCC
CACTVS 3.385CCCCCCCC=CCCCCCCCCC(=O)OC[CH](CO)OC(=O)CCCCCCCCC=CCCCCCCC
OpenEye OEToolkits 2.0.7CCCCCCCC=CCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC=CCCCCCCC
FormulaC39 H72 O5
Name[(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate
ChEMBL
DrugBank
ZINC
PDB chain7dxb Chain A Residue 909 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dxb Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		F606 F610
Binding residue
(residue number reindexed from 1)		F579 F583
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0046872 metal ion binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007338 single fertilization
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0033198 response to ATP
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dxb, PDBe:7dxb, PDBj:7dxb
PDBsum7dxb
PubMed35051376
UniProtQ13507|TRPC3_HUMAN Short transient receptor potential channel 3 (Gene Name=TRPC3)

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