Structure of PDB 7azg Chain D Binding Site BS01

Receptor Information

>7azg Chain D (length=368) Species: 1444266 (Escherichia coli 2-427-07_S4_C3)

SHMKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTD
LEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERML
VRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAH
QDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRK
GVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVL
PKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPE
QEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQ
IEDAASQSAAYVVMPMRL

Ligand information

>7azg Chain J (length=6) Species: 32630 (synthetic construct)

GQFDLF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7azg Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
• Resolution: 2.92 Å
• Binding residue (original residue number in PDB): R152 R365
• Binding residue (residue number reindexed from 1): R154 R367

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0005515 protein binding
• GO:0008408 3'-5' exonuclease activity
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006271 DNA strand elongation involved in DNA replication
• GO:0006974 DNA damage response
• GO:0030174 regulation of DNA-templated DNA replication initiation
• GO:0032297 negative regulation of DNA-templated DNA replication initiation
• GO:0042276 error-prone translesion synthesis
• GO:0044787 bacterial-type DNA replication

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0009360 DNA polymerase III complex
• GO:0030894 replisome
• GO:1990078 replication inhibiting complex
• GO:1990085 Hda-beta clamp complex

External links

• PDB: RCSB:7azg, PDBe:7azg, PDBj:7azg
• PDBsum: 7azg
• PubMed: 34806883
• UniProt: P0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)