Structure of PDB 7aqr Chain D Binding Site BS01

Receptor Information

>7aqr Chain D (length=385) Species: 3702 (Arabidopsis thaliana)

NFTLNFGPQHPAAHGVLRLVLEMNGEVVERAEPHIGLLHRGTEKLIEYKT
YLQALPYFDRLDYVSMMAQEHAYSLAVEKLLNCEVPLRAQYIRVLFCEIT
RILNHLLALTTHAMDVGALTPFLWAFEEREKLLEFYERVSGARMHASFIR
PGGVAQDLPLGLCRDIDSFTQQFASRIDELEEMLTGNRIWKQRLVDIGTV
TAQQAKDWGFSGVMLRGSGVCWDLRRAAPYDVYDQLDFDVPVGTRGDCYD
RYCIRIEEMRQSLRIIVQCLNQMPSGMIKADDRKLCPPSRCRMKLSMESL
IHHFELYTEGFSVPASSTYTAVEAPKGEFGVFLVSNGSNRPYRCKIRAPG
FAHSQGLDFMSKHHMLADVVTIIGTQDIVFGEVDR

Ligand information

>7aqr Chain Z (length=27) Species: 3702 (Arabidopsis thaliana)

PLLQDGPPPGGFAPVRYARRISNTGPS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7aqr A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
• Resolution: 2.91 Å
• Binding residue (original residue number in PDB): R97 L167 P168 L169 C172 D176 Q180 A183 D187 E190 E191 R269 L279 G285
• Binding residue (residue number reindexed from 1): R88 L158 P159 L160 C163 D167 Q171 A174 D178 E181 E182 R260 L270 G276

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016491 oxidoreductase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0048038 quinone binding
• GO:0051287 NAD binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7aqr, PDBe:7aqr, PDBj:7aqr
• PDBsum: 7aqr
• PubMed: 33768254
• UniProt: P93306|NDUS2_ARATH NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (Gene Name=NAD7)