Structure of PDB 6zz6 Chain D Binding Site BS01

Receptor Information
>6zz6 Chain D (length=1050) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTNCLTKLQMTIKNITLLRLLDVMVCNIKRYIALLSTIVLFNIESYIMEP
VNFLSDLIESLKDTFQEALELLPKYIRNGPFLDDNVTAKLVYIFSDLLMN
SFWDNVKRISSDILVSLFGSFDQQRGFIIEELLSHIEKLPTKRIQKKLRK
VQNIYITDFTFTLMSMLENINCYSFCNQMNIDLLKNEYKKQEEFLFNIVE
HINDTILERFFKNPSALRYVIDNFVQDLLLLISSPQWPVTEKILSSLLKR
LLSVYSPSMQVSANIETICLQLIGNIGSTIFDIKCSTRDHEDNNLITLPH
FFKSFEECIAYNETIKCRRSATRFLWNLRLGTILIITVDNELKKILEQIK
STIKLDYFSILHAFELLNLYDPYLKLILSLLAKDKIKLRSTAIKCLSMLA
SKDKVILSNPMVKETIHRRLNDSSASVKDAILDLVSINSSYFEFYQQINN
NYNDDSIMVRKHVLRINEKMYDETNDIVTKVYVIARILMKIEDEEDNIID
MARLILLNRWILKVHEVLDQPEKLKEISSSVLLVMSRVAIMNEKCSQLFD
LFLNFYLLNKEAHSKEAYDKITHVLTILTDFLVQKIVELNIVDKQNFLNL
LAKFADSTVSFLTKDHITALYPYMVSDSDFHYYILQVFRCTFEKLANFKQ
KFLYDLETTLLSRLPKMNVREIDEAMPLIWSVATHRHDTARVAKACSSCL
SHLHPYINKANGKLQRLIYLSTGFARFCFPKGETLYEHITKCLLVLSKDK
ITHVIRRVAVKNLTKLCGNHPKLFNSRHVLHLLDKEFQSDQLDIKLVILE
SLYDLFLLEERKSVRNTGVNSTLSSNGVCSALATRFLDNILQLCLLRDLK
NSLVAIRLLKLILKFGYTNPSHSIPTVIALFASTSQYIRHVAYELLEDLF
EKYETLVFSSLSRGVTKAIHYSIHTDEKYYYKHDHFLSLLEKLCGTGKKN
GPKFFKVLKRIMQSYLVQKSIFVLCTNISNITFVSQYDLVSLLKTIDLTT
DRLKEVIMDELSGIILIQLSLQDLGTYLLHLYESELKNKQFSAQLENIEQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zz6 Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R511 Q564 K721 K1325
Binding residue
(residue number reindexed from 1)		R218 Q271 K394 K949
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0043515 kinetochore binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006302 double-strand break repair
GO:0007064 mitotic sister chromatid cohesion
GO:0007076 mitotic chromosome condensation
GO:0010468 regulation of gene expression
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0061780 mitotic cohesin loading
GO:0070058 tRNA gene clustering
GO:0070550 rDNA chromatin condensation
GO:0071168 protein localization to chromatin
GO:0071169 establishment of protein localization to chromatin
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005729 2-micrometer circle DNA
GO:0005829 cytosol
GO:0032116 SMC loading complex
GO:0090694 Scc2-Scc4 cohesin loading complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zz6, PDBe:6zz6, PDBj:6zz6
PDBsum6zz6
PubMed32930661
UniProtQ04002|SCC2_YEAST Sister chromatid cohesion protein 2 (Gene Name=SCC2)

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