Structure of PDB 6x91 Chain D Binding Site BS01

Receptor Information
>6x91 Chain D (length=557) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEKDLLPNPPKTWEEIPALDKELKAKGNLQEPYFTWPLIAG
KYDIKDVGVDNAGAKAGLTFLVDLADTDYSIAEAAFNKGETAMNGPWAWS
NIDTSKVNYGVTVLPTFKGQPSKPFVGVLSINAASPNKELAKEFLENYLL
TDEGLEAVNKDKPLGAVALKSYEEELVKDPRIAATMENAQKGEIMPNIPQ
MSAFWYAVRTAVINAASGRQTVDEALKDAQTNSSSRRRIEPWEFDVFYDP
RELRKEACLLYEIKWGASSKIWRSSGKNTTNHVAVNFIKKFTSERDFHPS
TSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLFAHMDQQNRQ
GLRDLVNSGVTIQIMRDSEYYHCWRNFVNYPPGDEAHWPQYPPAWMMLYA
LELHCIILSLPPCLKISRRAQNHLTAFRLHLQNCHYQTIPPHILLATGLI
HPSVAWR
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain6x91 Chain N Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x91 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
Resolution3.51 Å
Binding residue
(original residue number in PDB)		E112 Y156
Binding residue
(residue number reindexed from 1)		E111 Y142
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.36: mRNA(cytosine(6666)) deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0046872 metal ion binding
GO:1901982 maltose binding
Biological Process
GO:0006397 mRNA processing
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0010332 response to gamma radiation
GO:0015768 maltose transport
GO:0016554 cytidine to uridine editing
GO:0016556 mRNA modification
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042953 lipoprotein transport
GO:0042956 maltodextrin transmembrane transport
GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation
GO:0048255 mRNA stabilization
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
GO:0090209 negative regulation of triglyceride metabolic process
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0030895 apolipoprotein B mRNA editing enzyme complex
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0045293 mRNA editing complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x91, PDBe:6x91, PDBj:6x91
PDBsum6x91
PubMed33094286
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P41238

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