Structure of PDB 6wrs Chain D Binding Site BS01

Receptor Information

>6wrs Chain D (length=100) Species: 1280 (Staphylococcus aureus)

MFAIIETGGKQIKVEEGQEIFVEKLDVNEGDTFTFDKVLFVGGDSVKVGA
PTVEGATVTATVNKQGRGKKITVFTYKRRKNSKRKKGHRQPYTKLTIDKI

Ligand information

>6wrs Chain 1 (length=2698)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagu
cagaacaugggugauaagguccguguucgaaagggaaacagcccagacca
ccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugc
cacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccga
agcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguu
gaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggu
gugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguu
uccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggc
cgacaggcguaggcgauggauaacagguugauauuccuguaccaccuaua
aucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggau
ugcacgucuaagcaguaaggcuguccgguagcugagcugugauggggaga
agaccuucgagucguugauuucacacugccgagaaaagccucuagauaga
aaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauuc
uaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccgu
aacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgca
gugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaac
cguaaggugauguauaggggcugacgccugcccagugcuggaagguuaag
aggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggc
ggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaagu
uccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagaga
cucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggac
ggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuu
cuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuu
gacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguuccc
ucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuug
acugcgagaccuacaagucgagcagggucgaaagacggacuuagugaucc
ggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgg
ggauaacaggcuuaucucccccaagaguucacaucgacggggagguuugg
caccucgaugucggcucaucgcauccuggggcuguagucggucccaaggg
uugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucg
ugagacaguucggucccuauccgucgugggcguaggaaauuugagaggag
cuguccuuaguacgagaggaccgggauggacauaccucugguguaccagu
ugucgugccaacggcauagcuggguagcuauguguggacgggauaagugc
ugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuuc
gguuauaagaucccucaaagaugaugagguuaauagguucgagguggaag
cauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<...........>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<<.<...
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>.....>.>>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>.............}....>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>
..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<
<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<.
.......>>>>.>>>>.>>...........))).....>>>>>>.>>>..
.>>>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<...
...<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>>
<......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<
<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<.
......<<...<<<<....<<<<...<<...<....<.<...........
..>.>.<<...<<<<...<<<.........>>>...>>>>....>>....
.<....>........>....>>...>>>>.........>>>>..>>....
..>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>
>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<..
...<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>....
........<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<
<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<
<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>>
<<<<<<.......>>>>>>........<...........<<<<<......
.>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.
>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.
[[......<<<<.[[<<<<..<<<<..<<<<<<<<<.<<<<.<..>.>>>
>....<<.<<<<<.......>>>>>>>.....>>>>>>>>>...>>>>..
<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<
...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>..
.<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<
<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>
>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>
>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>
.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<.
...>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..
<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<
<<<<<......>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<
<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<...
.>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<
<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wrs Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): F21 K64 R67 K70 R78 R79 N81 R84 K85 K86 G87 H88 Q90 Y92
• Binding residue (residue number reindexed from 1): F21 K64 R67 K70 R78 R79 N81 R84 K85 K86 G87 H88 Q90 Y92

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6wrs, PDBe:6wrs, PDBj:6wrs
• PDBsum: 6wrs
• PubMed: 32566908
• UniProt: Q2FXS8|RL21_STAA8 Large ribosomal subunit protein bL21 (Gene Name=rplU)