Structure of PDB 6waa Chain D Binding Site BS01

Receptor Information
>6waa Chain D (length=637) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILN
TWEVSSDEVLASQEVHDISVAIGIDPDSDYGKICILADADSDGLHIATLL
CALFVRHFRTLVKEGHVYVALPPLYALTEEEKTGVRFKGLGEMNPMQLRE
TTLDPNTRRLVQLISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEKGRLAL
HEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPD
DPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPAR
LPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIV
QGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVALPHQVSGAKVLEQIA
AQMRNKKLPMVDDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLL
EILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIR
TEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKER
DQLQAILASERKMNNLLKKELQADADAFGDDRRSPLH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		L446 N447 S459 H498 K610 Y1120 I1172 A1173 G1175 M1176 T1318 S1324 R1326
Binding residue
(residue number reindexed from 1)		L49 N50 S62 H95 K182 Y310 I362 A363 G365 M366 T474 S480 R482
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6waa, PDBe:6waa, PDBj:6waa
PDBsum6waa
PubMed32634310
UniProtB5XU60

[Back to BioLiP]