Structure of PDB 6w8b Chain D Binding Site BS01
Receptor Information
>6w8b Chain D (length=285) Species:
9606
(Homo sapiens) [
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AEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRH
QGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNP
VMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKF
SKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDV
SNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
>6w8b Chain E (length=25) [
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catgugatctaattagatcgcatgg
Receptor-Ligand Complex Structure
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PDB
6w8b
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
S708 C710 N711 S714 V716 N717 E756 V758 R792 R831 T832 T834 T835 R836 G890 R891
Binding residue
(residue number reindexed from 1)
S81 C83 N84 S87 V89 N90 E129 V131 R165 R204 T205 T207 T208 R209 G263 R264
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168
methyltransferase activity
View graph for
Molecular Function
External links
PDB
RCSB:6w8b
,
PDBe:6w8b
,
PDBj:6w8b
PDBsum
6w8b
PubMed
32385248
UniProt
Q9Y6K1
|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)
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