Structure of PDB 6vxz Chain D Binding Site BS01

Receptor Information
>6vxz Chain D (length=389) Species: 869211 (Spirochaeta thermophila DSM 6578) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADI
PLDLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSAT
RILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSA
FYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVS
KLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEER
EVLKELPHPLRLAVAMEIHGDVIEKVALFKGAGEEFIRDIILHLEPVIYG
PGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALIL
RAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain6vxz Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vxz Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.
Resolution3.42 Å
Binding residue
(original residue number in PDB)		Y357 G367 E368 M369 R377
Binding residue
(residue number reindexed from 1)		Y334 G344 E345 M346 R354
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6vxz, PDBe:6vxz, PDBj:6vxz
PDBsum6vxz
PubMed33328472
UniProtG0GA88

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