Structure of PDB 6vch Chain D Binding Site BS01

Receptor Information

>6vch Chain D (length=452) Species: 1078905 (Candidatus Nitrosotalea devanaterra)

NKFQLGFSTLSEELDLESLQVKGTIPKWLSGTLIRNGPAKFEVGKEKFQH
WFDGLAMLHKFSFKEGKVSYANKFLESKAYQSARDTDKISYREFATDPCF
TDNANVNVTKIAERFVAMTETPLPVEFDINTLKTVGVFAYDDKIESGLTT
AHPHYDFVKNELVNYATKISRSSNYNVYKIADKTNHRNLIGSIPVEEPAY
MHSFAMTENYVVLVEYPFVVKPLDLLLSGKPFIENFSWKPENGTRFIIVN
RQNGNLVGTYKSDAFFAFHHVNAFEKQEEIFVDIIAYQDSSIVNALYLDI
LRGQKTDTIPTSHIRRYRIPLSGGQVEYEMLSSEAVELPRINYKQYNTKD
YRFVYGISTYSASDFANQLVKIDILRKSSKIWSEKDCYPGEPVFVGAPDA
TKEDEGLILSAVLDATNAKSFLLILDATTFEEVARAEVPHHIPFGFHGNY
FE

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 6vch Chain D Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vch Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): H172 H222 H289 H467
• Binding residue (residue number reindexed from 1): H152 H202 H269 H447
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003834 beta-carotene 15,15'-dioxygenase activity
• GO:0010436 carotenoid dioxygenase activity
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0016121 carotene catabolic process

External links

• PDB: RCSB:6vch, PDBe:6vch, PDBj:6vch
• PDBsum: 6vch
• PubMed: 32747548
• UniProt: A0A128A3G4