Structure of PDB 6vcg Chain D Binding Site BS01

Receptor Information

>6vcg Chain D (length=453) Species: 1078905 (Candidatus Nitrosotalea devanaterra)

TNKFQLGFSTLSEELDLESLQVKGTIPKWLSGTLIRNGPAKFEVGKEKFQ
HWFDGLAMLHKFSFKEGKVSYANKFLESKAYQSARDTDKISYREFATDPC
FTDNANVNVTKIAERFVAMTETPLPVEFDINTLKTVGVFAYDDKIESGLT
TAHPHYDFVKNELVNYATKISRSSNYNVYKIADKTNHRNLIGSIPVEEPA
YMHSFAMTENYVVLVEYPFVVKPLDLLLSGKPFIENFSWKPENGTRFIIV
NRQNGNLVGTYKSDAFFAFHHVNAFEKQEEIFVDIIAYQDSSIVNALYLD
ILRGQKTDTIPTSHIRRYRIPLSGGQVEYEMLSSEAVELPRINYKQYNTK
DYRFVYGISTYSASDFANQLVKIDILRKSSKIWSEKDCYPGEPVFVGAPD
ATKEDEGLILSAVLDATNAKSFLLILDATTFEEVARAEVPHHIPFGFHGN
YFE

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 6vcg Chain D Residue 1000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vcg Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): H172 H222 H289 H467
• Binding residue (residue number reindexed from 1): H153 H203 H270 H448
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003834 beta-carotene 15,15'-dioxygenase activity
• GO:0010436 carotenoid dioxygenase activity
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0016121 carotene catabolic process

External links

• PDB: RCSB:6vcg, PDBe:6vcg, PDBj:6vcg
• PDBsum: 6vcg
• PubMed: 32747548
• UniProt: A0A128A3G4