Structure of PDB 6v38 Chain D Binding Site BS01

Receptor Information
>6v38 Chain D (length=874) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTWMTSVKDWAGVMISAQT
LTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVF
FLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFL
RALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENS
GDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFIL
GGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNF
LKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPH
DLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQ
MLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLAN
LFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFV
KLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKKYDSTGMFHWC
APKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASN
FHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNIN
LCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGVNIPIITEL
VNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDN
ILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLAL
LDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRY
VITNPPYEFELVPTDLIFCLMQFD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6v38 Chain D Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v38 Molecular structures of the human Slo1 K + channel in complex with beta 4.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		D367 R514 S533 E535 S600
Binding residue
(residue number reindexed from 1)		D308 R455 S474 E476 S525
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v38, PDBe:6v38, PDBj:6v38
PDBsum6v38
PubMed31815672
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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