Structure of PDB 6uon Chain D Binding Site BS01
Receptor Information
>6uon Chain D (length=273) Species:
9606
(Homo sapiens) [
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SHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPW
VEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGC
DLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAR
EAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATL
RCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPS
GEEQRYTCHVQHEGLPEPLTLRW
Ligand information
>6uon Chain F (length=10) Species:
9606
(Homo sapiens) [
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GADGVGKSAL
Receptor-Ligand Complex Structure
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PDB
6uon
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.
Resolution
3.5 Å
Binding residue
(original residue number in PDB)
Y7 E63 K66 T73 S77 N80 Y99 K146 W147 E152 Q155 R156 Y159 W167
Binding residue
(residue number reindexed from 1)
Y6 E62 K65 T72 S76 N79 Y98 K145 W146 E151 Q154 R155 Y158 W166
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6uon
,
PDBe:6uon
,
PDBj:6uon
PDBsum
6uon
PubMed
32461371
UniProt
C1K0Y1
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