Structure of PDB 6uiw Chain D Binding Site BS01

Receptor Information
>6uiw Chain D (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIG
VPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAV
APVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPC
KENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPL
SYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEE
LIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGL
Ligand information
Ligand IDR2R
InChIInChI=1S/14H2N.2O.3Ru/h14*1H2;;;;;/q14*-1;;;+4;2*+5
InChIKeyFOOPNNMQSUSGAT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		N[Ru](N)(N)(N)(N)O[Ru](N)(N)(N)(N)O[Ru](N)(N)(N)(N)N
ACDLabs 12.01N[Ru](N)(N)(N)(O[Ru](N)(N)(N)(N)N)O[Ru](N)(N)(N)(N)N
FormulaH28 N14 O2 Ru3
Nameruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
ChEMBL
DrugBank
ZINC
PDB chain6uiw Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6uiw The structures and gating mechanism of human calcium homeostasis modulator 2.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		F39 W117 R124
Binding residue
(residue number reindexed from 1)		F27 W105 R112
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0043065 positive regulation of apoptotic process
GO:0048167 regulation of synaptic plasticity
GO:0070509 calcium ion import
GO:0098655 monoatomic cation transmembrane transport
GO:1903978 regulation of microglial cell activation
GO:1904669 ATP export
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uiw, PDBe:6uiw, PDBj:6uiw
PDBsum6uiw
PubMed31776515
UniProtQ9HA72|CAHM2_HUMAN Calcium homeostasis modulator protein 2 (Gene Name=CALHM2)

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