Structure of PDB 6u8x Chain D Binding Site BS01
Receptor Information
>6u8x Chain D (length=291) Species:
9606
(Homo sapiens) [
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LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
>6u8x Chain E (length=25) [
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catguagtctaattagactgcatgg
Receptor-Ligand Complex Structure
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PDB
6u8x
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Resolution
2.95064 Å
Binding residue
(original residue number in PDB)
S649 C651 N652 S655 V657 N658 E697 V699 R733 Q772 T773 T776 K777 G784 G831 R832
Binding residue
(residue number reindexed from 1)
S87 C89 N90 S93 V95 N96 E135 V137 R171 Q210 T211 T214 K215 G222 G269 R270
Enzymatic activity
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168
methyltransferase activity
View graph for
Molecular Function
External links
PDB
RCSB:6u8x
,
PDBe:6u8x
,
PDBj:6u8x
PDBsum
6u8x
PubMed
32620778
UniProt
Q9UBC3
|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)
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