Structure of PDB 6u8p Chain D Binding Site BS01

Receptor Information
>6u8p Chain D (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u8p Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		S649 C651 N652 S655 V657 N658 E697 V699 R733 Q772 T773 T775 T776 K777 G831 R832
Binding residue
(residue number reindexed from 1)		S87 C89 N90 S93 V95 N96 E135 V137 R171 Q210 T211 T213 T214 K215 G269 R270
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6u8p, PDBe:6u8p, PDBj:6u8p
PDBsum6u8p
PubMed32620778
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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