Structure of PDB 6u6z Chain D Binding Site BS01
Receptor Information
>6u6z Chain D (length=420) Species:
9606
(Homo sapiens) [
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GKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDAEQLIRVYCKKVDRKSL
YAARQYFVQWCADRNFTKPQ
Ligand information
>6u6z Chain E (length=4) [
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tgut
Receptor-Ligand Complex Structure
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PDB
6u6z
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
K116 V117 I118 H125 D137 Q142 R145
Binding residue
(residue number reindexed from 1)
K2 V3 I4 H11 D23 Q28 R31
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6z
,
PDBe:6u6z
,
PDBj:6u6z
PDBsum
6u6z
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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