Structure of PDB 6u6x Chain D Binding Site BS01
Receptor Information
>6u6x Chain D (length=430) Species:
9606
(Homo sapiens) [
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TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRIDVAKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDIDHVSFYCAEQLIRVY
CKKVDRKSLYAARQYFVQWCADRNFTKPQD
Ligand information
>6u6x Chain E (length=4) [
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cgcc
Receptor-Ligand Complex Structure
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PDB
6u6x
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.58 Å
Binding residue
(original residue number in PDB)
V117 I118 H125 D137 R145
Binding residue
(residue number reindexed from 1)
V4 I5 H12 D24 R32
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6x
,
PDBe:6u6x
,
PDBj:6u6x
PDBsum
6u6x
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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