Structure of PDB 6ttu Chain D Binding Site BS01

Receptor Information
>6ttu Chain D (length=146) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALKRIHKELNDLARDPPAQISAGPVGDDMFHWQATIMGPNDSPYQGGVFF
LTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISK
VLLSIASLLDDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM
Ligand information
Receptor-Ligand Complex Structure
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PDB6ttu NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C85 D117 P118
Binding residue
(residue number reindexed from 1)		C84 D116 P117
Enzymatic activity
Enzyme Commision number 2.3.2.23: E2 ubiquitin-conjugating enzyme.
2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0036211 protein modification process
GO:0051865 protein autoubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ttu, PDBe:6ttu, PDBj:6ttu
PDBsum6ttu
PubMed32051583
UniProtP62837|UB2D2_HUMAN Ubiquitin-conjugating enzyme E2 D2 (Gene Name=UBE2D2)

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