Structure of PDB 6t2u Chain D Binding Site BS01

Receptor Information
>6t2u Chain D (length=597) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLE
NNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYL
NRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAA
VALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAA
ARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGN
PLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAV
LGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSY
RFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLE
EALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIE
QFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTR
VWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTP
VVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSS
Ligand information
>6t2u Chain X (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttttttttttttgagcgactgcactacaacgttgtagtgcagtcgctctt
tttt
Receptor-Ligand Complex Structure
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PDB6t2u A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		T205 T239 H241 R242 A246 Q247 P248 V304 R445 N487 T537 H539 V560
Binding residue
(residue number reindexed from 1)		T196 T230 H232 R233 A237 Q238 P239 V295 R436 N478 T528 H530 V551
Enzymatic activity
Enzyme Commision number 5.6.2.3: DNA 5'-3' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0008854 exodeoxyribonuclease V activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0009338 exodeoxyribonuclease V complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t2u, PDBe:6t2u, PDBj:6t2u
PDBsum6t2u
PubMed31907455
UniProtP04993|RECD_ECOLI RecBCD enzyme subunit RecD (Gene Name=recD)

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