Structure of PDB 6ru8 Chain D Binding Site BS01

Receptor Information
>6ru8 Chain D (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
Ligand information
Receptor-Ligand Complex Structure
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PDB6ru8 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		S19 D128 K130 L152 L173 T174 G175 T176 R178 Q214 G215 K224 Y225
Binding residue
(residue number reindexed from 1)		S18 D127 K129 L151 L172 T173 G174 T175 R177 Q213 G214 K223 Y224
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ru8, PDBe:6ru8, PDBj:6ru8
PDBsum6ru8
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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