Structure of PDB 6rmm Chain D Binding Site BS01
Receptor Information
>6rmm Chain D (length=190) Species:
9606
(Homo sapiens) [
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LFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGC
EVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVI
SFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERG
GSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENS
Ligand information
>6rmm Chain P (length=9) Species:
9606
(Homo sapiens) [
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SDLVAPSPD
Receptor-Ligand Complex Structure
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PDB
6rmm
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Resolution
3.53 Å
Binding residue
(original residue number in PDB)
E677 Y678 F679 V680 R681 M689 K704
Binding residue
(residue number reindexed from 1)
E126 Y127 F128 V129 R130 M138 K153
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6rmm
,
PDBe:6rmm
,
PDBj:6rmm
PDBsum
6rmm
PubMed
31135337
UniProt
Q92547
|TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (Gene Name=TOPBP1)
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