Structure of PDB 6qtk Chain D Binding Site BS01

Receptor Information

>6qtk Chain D (length=192) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNV
EKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGA
HIRTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNP
EHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYA

Ligand information

>6qtk Chain E (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agccgtaggtacctacggct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6qtk Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Resolution	2.31 Å
Binding residue (original residue number in PDB)	K460 L462 N463 K466 R471 H515 V626 R629
Binding residue (residue number reindexed from 1)	K46 L48 N49 K52 R57 H101 V178 R181

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:6qtk, PDBe:6qtk, PDBj:6qtk
PDBsum	6qtk
PubMed	30757898
UniProt	P66937\|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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