Structure of PDB 6qsk Chain D Binding Site BS01

Receptor Information
>6qsk Chain D (length=294) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLI
ILRILGFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNL
TIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQFNPGYFWMF
TNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWS
SVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNK
LPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQ
Ligand information
Ligand ID5GP
InChIInChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyRQFCJASXJCIDSX-UUOKFMHZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3O)COP(=O)(O)O
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H14 N5 O8 P
NameGUANOSINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL283807
DrugBankDB01972
ZINCZINC000002159505
PDB chain6qsk Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qsk Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer.
Resolution3.394 Å
Binding residue
(original residue number in PDB)		M98 S269 Y281 K289
Binding residue
(residue number reindexed from 1)		M78 S230 Y242 K250
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005458 GDP-mannose transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0055085 transmembrane transport
GO:1990570 GDP-mannose transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qsk, PDBe:6qsk, PDBj:6qsk
PDBsum6qsk
PubMed31604945
UniProtP40107|GMT1_YEAST GDP-mannose transporter 1 (Gene Name=VRG4)

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