Structure of PDB 6qnp Chain D Binding Site BS01

Receptor Information
>6qnp Chain D (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVII
DMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHT
MTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQI
INYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQ
FKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFP
PEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETI
FVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAV
RNNL
Ligand information
>6qnp Chain K (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SQPLIDLPLIDFCPVVGQLIDLSS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6qnp Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R64 P65 I66 S67 L82 K83 A84 Q89 F91 K96 K98 A101 H102 T103 H145 W164 L183 V190 S191 Q192 I231
Binding residue
(residue number reindexed from 1)		R61 P62 I63 S64 L79 K80 A81 Q86 F88 K93 K95 A98 H99 T100 H142 W161 L180 V187 S188 Q189 I228
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6qnp, PDBe:6qnp, PDBj:6qnp
PDBsum6qnp
PubMed31932847
UniProtQ00610|CLH1_HUMAN Clathrin heavy chain 1 (Gene Name=CLTC)

[Back to BioLiP]