Structure of PDB 6qkc Chain D Binding Site BS01

Receptor Information
>6qkc Chain D (length=396) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV
GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPF
MSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR
EFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTAN
LAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK
MWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCD
TMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYD
KGECGGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
Ligand information
Ligand IDE2Q
InChIInChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
InChIKeyUQNAFPHGVPVTAL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385N[S](=O)(=O)c1cccc2c3NC(=O)C(=O)Nc3cc(c12)[N+]([O-])=O
OpenEye OEToolkits 2.0.6c1cc2c(c(c1)S(=O)(=O)N)c(cc3c2NC(=O)C(=O)N3)[N+](=O)[O-]
FormulaC12 H8 N4 O6 S
Name6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide
ChEMBLCHEMBL222519
DrugBank
ZINCZINC000008585017
PDB chain6qkc Chain D Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6qkc Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		Y450 P478 L479 T480 R485 E705 M708
Binding residue
(residue number reindexed from 1)		Y55 P83 L84 T85 R90 E286 M289
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qkc, PDBe:6qkc, PDBj:6qkc
PDBsum6qkc
PubMed30872532
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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