Structure of PDB 6q0r Chain D Binding Site BS01

Receptor Information
>6q0r Chain D (length=82) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFIT
FSDSECAKKALEQLNGFELAGRPMKVGHVTER
Ligand information
Ligand IDO6M
InChIInChI=1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
InChIKeyLWGUASZLXHYWIV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01c1(cccc(c1)S(Nc2ccc(C)c3c(cnc23)C#N)(=O)=O)C#N
OpenEye OEToolkits 2.0.7Cc1ccc(c2c1c(c[nH]2)C#N)NS(=O)(=O)c3cccc(c3)C#N
CACTVS 3.385Cc1ccc(N[S](=O)(=O)c2cccc(c2)C#N)c3[nH]cc(C#N)c13
FormulaC17 H12 N4 O2 S
Name3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide
ChEMBLCHEMBL4297376
DrugBankDB12505
ZINCZINC000000008704
PDB chain6q0r Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6q0r Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		T262 D264 M265
Binding residue
(residue number reindexed from 1)		T15 D17 M18
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6q0r, PDBe:6q0r, PDBj:6q0r
PDBsum6q0r
PubMed31686031
UniProtQ14498|RBM39_HUMAN RNA-binding protein 39 (Gene Name=RBM39)

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