Structure of PDB 6nfj Chain D Binding Site BS01

Receptor Information
>6nfj Chain D (length=846) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSGDGRAIWSDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHV
SSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG
LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDY
ATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGH
NLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQQ
SMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFA
FSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFT
DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA
YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGTPDVQGQFPCDFSW
GVTESVLKPCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGQLSAVN
RQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPST
AEAFQAYAGLCFQELGDLVKLWITINEPNRLSDNDTYGAAHNLLVAHALA
WRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF
AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCA
LNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKL
LRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDK
VRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFP
Ligand information
Receptor-Ligand Complex Structure
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PDB6nfj Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		W419 M435 F826 F849 L850 Q851 F931 F942
Binding residue
(residue number reindexed from 1)		W348 M364 F704 F727 L728 Q729 F809 F820
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nfj, PDBe:6nfj, PDBj:6nfj
PDBsum6nfj
PubMed30944224
UniProtQ86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)

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