Structure of PDB 6n7x Chain D Binding Site BS01

Receptor Information
>6n7x Chain D (length=539) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKYTALIHDENFSTLTLNVSRYPKSLAYWEKLLNYIVKASAPICKSTEPQ
LLKLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSHKIFQRGLQAF
NQRSLLLWTSYLKFCNNVISHQKQLFKKYETAEEYVGLHFFSGEFWDLYL
EQISSRCTSSKKYWNVLRKILEIPLHSFSKFYALWLQRIDDIMDLKQLSQ
LTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQYQVLEI
YSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQR
ALLPLAHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKLL
YSVICKLNEYVLLRNLLEKIESSYSDNVENVDDFEIFWDYLQFKTFCQNS
LYSSRYSDSQSNGLLNKELFDKVWKRLSCKEKKSGQEILLNNLVQFYSKD
TVEFVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFDTSRSYLDKRQYI
VRKIWPQIDKKFAQSVLPSLTEFCESYFPEEMDTLEEMF
Ligand information
>6n7x Chain R (length=308) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaagauaucagaggaaaguccucugaucaaacaugcgcuuccaauaguag
aaggacguuaagcauuuaucauugaacuaguucauugaagucauugaugc
aaacuccuuggucacacacggcgcggaaggcguguuugcugacguuccau
ucccuuguuucaaucauugguuaacugauuuuuggggcccuuuguuucuu
cugccuggagaaguuugacaccaaauauugguguuaggggagcuggggcc
uuucaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuu
ugauuuau
<<<<<.<<<<<<<<.....>>>>>>>><<<<<<<<<.<<<<<........
<<<<<.<<<..<<<<.<.<<<.<<<<<..>>>>>.>>>.......>>>>>
.>>>>>>>>...............>>>>>>>>>>>>>><<<.<<<<<<..
<<<<<.<<<<<<<..<<<<<<..>>>>>>..>>>>>>>((.......<<<
<<....))>>>>>...<<<<<<<<...>>>>>>>>.>>>>><<<<<<<<<
<<<<<<<<>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>>.......
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6n7x CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		S88 M89 H91 H122 Q123 Q125 C158 T159 M194 D195 L196 R221 K222 G223
Binding residue
(residue number reindexed from 1)		S87 M88 H90 H121 Q122 Q124 C157 T158 M193 D194 L195 R220 K221 G222
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0030627 pre-mRNA 5'-splice site binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6n7x, PDBe:6n7x, PDBj:6n7x
PDBsum6n7x
PubMed29051543
UniProtQ03776|PRP42_YEAST U1 small nuclear ribonucleoprotein component PRP42 (Gene Name=PRP42)

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