Structure of PDB 6mdo Chain D Binding Site BS01

Receptor Information
>6mdo Chain D (length=525) Species: 10029 (Cricetulus griseus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGIL
LYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFA
DAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK
IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQIL
HIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI
IVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDP
VTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFP
FIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVP
IGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFST
TIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLML
IEMSLQMDPEYRVRKFLALLREEGA
Ligand information
>6mdo Chain H (length=17) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MAEDADMRNELEEMQRR
Receptor-Ligand Complex Structure
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PDB6mdo Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K293 Y294 H347
Binding residue
(residue number reindexed from 1)		K86 Y87 H140
Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Gene Ontology
Molecular Function
GO:0000149 SNARE binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030165 PDZ domain binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0140545 ATP-dependent protein disaggregase activity
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0035494 SNARE complex disassembly
GO:0043001 Golgi to plasma membrane protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030496 midbody

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mdo, PDBe:6mdo, PDBj:6mdo
PDBsum6mdo
PubMed30198481
UniProtP18708|NSF_CRIGR Vesicle-fusing ATPase (Gene Name=NSF)

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