Structure of PDB 6m6a Chain D Binding Site BS01

Receptor Information
>6m6a Chain D (length=1304) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGP
IKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHI
WFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQL
LTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV
ALYRFPREPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDV
YGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEM
KHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVD
GGRFATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDAL
LDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVI
VVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQR
DIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPL
VCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKP
SRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAG
RETSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRIL
FARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLL
DALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMG
FLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGN
PQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGG
ADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRS
LRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAG
EIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGE
PGTQLQGLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEG
FSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYL
VEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKW
DVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLT
EAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEA
RKEA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m6a Structural basis of Mfd-dependent transcription termination.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		P484 R486
Binding residue
(residue number reindexed from 1)		P303 R305
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m6a, PDBe:6m6a, PDBj:6m6a
PDBsum6m6a
PubMed33068413
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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