Structure of PDB 6lz1 Chain D Binding Site BS01

Receptor Information
>6lz1 Chain D (length=1076) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLFPVLNNTPVGKQVDSIYESRLDQFLSEGQYRDFNLPSVYDHARIDNPS
GDVNNDLSKGFVDLKVYRVPDLSRPSFNEVVGHKKFDETASKGDTFGPSW
ATFWFEVHIRLPKSWAKYEQVIFQWNCDNEGLVYSQDGVPLQAFSGSERT
DFILPDSWKTTEDTFYIEMACNGMFGTGAGSQIAPPDPNRYFTLTKADLV
APNLPAMALAYDFLLMQQCVKQLPSNCWQKYKARQICNDIMNTFHPNDLS
TINECRNLAKAFLGNDIDSEAVFEKNNDKANVFAIGHCHIDTAWLWPFAE
TRRKIVRSWATQMNIMDRYPEYQFVCSQALQYLWLKEDHPDVFEKLKEYV
NQNKFIPIGGSWVEHDTNIPNGESLIRQFLLGQHFFEKEFGVRCRTFWLP
DTFGYSSQIPQICRLCGMDRFLTQKLSWNNINSFPTSTFNWVALDGSQVI
CHMPPANTYTADTNVNDVLHSIDQHKNLVNDQAGLLVFGIGDGGGGPTPE
MLEKLRRCKGIANTVGYLPNVKLGNTVDEFFDGILKRTNAGQTLPSWNGE
LYFEFHRGTYTTQAELKKLMRKVEIALHDAEYVSTLASIFSKDYSYPKES
LQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMSKVLKNTEALLWQAIEQ
LGFKKASSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESCDGKGILT
AAHTSLKHPAAAYQKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILD
LKSGKNHAGANQYVLFEDTPLSWQAWDTEVFSLEKYEVLDKGKVSIKESG
PLRASVVVDIPISELSHMKATISLEGYNDCSEFTGVNFTCEVDWHESCKF
LKVEFPVDIHSEFASYETQFGITKRPTHYNTSWDVAKFEVCHQKFADYSD
FTYGVSVLNDCKYGFSTHGNLMRLSLLRSPKQPDAHADMGKHTIRYAVYP
HSKPLDSSTVRAAHKFNSNFRLLTRASDTANLDIFDAFQLVGEPNVILSH
IKMAEKGKSIILRVYESLGGKSRARLVIKSLTVASVTKCNGLEEDLEELC
TLKSNDYYEVPIELRAFEIATFKVNL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6lz1 Chain D Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lz1 Cryo-EM structure of fission yeast tetrameric alpha-mannosidase Ams1.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D292 D402
Binding residue
(residue number reindexed from 1)		D291 D401
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
GO:0052768 mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0000328 fungal-type vacuole lumen
GO:0000329 fungal-type vacuole membrane
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lz1, PDBe:6lz1, PDBj:6lz1
PDBsum6lz1
PubMed32981237
UniProtQ9UT61|MAN1_SCHPO Alpha-mannosidase (Gene Name=ams1)

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