Structure of PDB 6l1p Chain D Binding Site BS01

Receptor Information
>6l1p Chain D (length=69) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWS
HRYDEWIYWDSNRLRPLER
Ligand information
Ligand IDE3X
InChIInChI=1S/C12H15NO/c1-13-8-6-11(7-9-13)10-2-4-12(14)5-3-10/h2-6,14H,7-9H2,1H3
InChIKeyGIGCUVKCMPXMAZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CN1CCC(=CC1)c2ccc(cc2)O
CACTVS 3.385CN1CCC(=CC1)c2ccc(O)cc2
FormulaC12 H15 N O
Name4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenol
ChEMBLCHEMBL108967
DrugBank
ZINCZINC000001706757
PDB chain6l1p Chain D Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6l1p Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
Resolution1.231 Å
Binding residue
(original residue number in PDB)		D23 L25 Y29 F47 W50 Y54
Binding residue
(residue number reindexed from 1)		D22 L24 Y28 F46 W49 Y53
Annotation score1
Binding affinityMOAD: Kd=0.31mM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6l1p, PDBe:6l1p, PDBj:6l1p
PDBsum6l1p
PubMed32885980
UniProtA8MW92|P20L1_HUMAN PHD finger protein 20-like protein 1 (Gene Name=PHF20L1)

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