Structure of PDB 6kyv Chain D Binding Site BS01

Receptor Information
>6kyv Chain D (length=672) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICK
DLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKL
QELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALK
NWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNIL
IATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSN
AGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQ
PKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRP
HPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVED
IATGVQTLYSKWKDFHFEKIPF
Ligand information
>6kyv Chain C (length=22) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguagacgcuucggcguuugcc
<<<<<<<<<<..>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kyv Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q299 I300 S325 G326 T347 Q349 Q380 H381 Q498 E510 Q511 V514 R546 K635 T636 R637 G663 R664 N668 Q678 T697 S698 K750 H830 F853 K858 I875 V886 K888 W908
Binding residue
(residue number reindexed from 1)		Q58 I59 S84 G85 T106 Q108 Q139 H140 Q257 E269 Q270 V273 R305 K391 T392 R393 G419 R420 N424 Q434 T453 S454 K506 H584 F607 K612 I629 V640 K642 W662
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6kyv, PDBe:6kyv, PDBj:6kyv
PDBsum6kyv
PubMed31852354
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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