Structure of PDB 6k8p Chain D Binding Site BS01

Receptor Information
>6k8p Chain D (length=280) Species: 763924 (Phytophthora capsici LT1534) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVLHLGLRAGQVANRIVSVGSLGRAKVLAQLLDEGHFETFESARGFTTYS
GKVKGVPVSIVATGMGVPNMDFVVRETRAVVNGPMTIIRFGTCGAVREEV
PPGSVVVNGKGSIMVTRNPDAFFPGASEEDCYRVSRVMPSSSTLSKALVA
SMEDKLTALRAEPVIAASSDCDALRVFDGLNATACSFYSSQGRLDSNFDD
RNEKLVEDLTTAHPDLYTVEMETFHLLDLAQRSRGSIQATAAVLVVANRL
SGQIVESEVLEALESFWGGVVLQTIVSTPL
Ligand information
Ligand IDTHM
InChIInChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
InChIKeyIQFYYKKMVGJFEH-XLPZGREQSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
CACTVS 3.341CC1=CN([CH]2C[CH](O)[CH](CO)O2)C(=O)NC1=O
ACDLabs 10.04O=C1NC(=O)N(C=C1C)C2OC(C(O)C2)CO
CACTVS 3.341CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
OpenEye OEToolkits 1.5.0CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
FormulaC10 H14 N2 O5
NameTHYMIDINE;
DEOXYTHYMIDINE;
2'-DEOXYTHYMIDINE
ChEMBLCHEMBL52609
DrugBankDB04485
ZINCZINC000000025672
PDB chain6k8p Chain C Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k8p Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.
Resolution1.965 Å
Binding residue
(original residue number in PDB)		H19 R59
Binding residue
(residue number reindexed from 1)		H4 R44
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k8p, PDBe:6k8p, PDBj:6k8p
PDBsum6k8p
PubMed32493959
UniProtA0A410UCT3

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