Structure of PDB 6ict Chain D Binding Site BS01

Receptor Information
>6ict Chain D (length=479) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSPKEILNLTSELLQKCSSPAPGKEWEEYVQIRTLVEKIRKKQKGLSVTF
DGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFL
WVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSF
WQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFY
KVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALI
PLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEF
VIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALH
FTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWD
NEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGE
KEILEKAVKSAAVNREYYRQQMEEKAPLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ict Structural insights into SETD3-mediated histidine methylation on beta-actin.
Resolution1.952 Å
Binding residue
(original residue number in PDB)		M152 N154 I155 N212 R215 Q216 V248 M252 R254 Q255 N256 W274 D275 T286 G287 Y288 L290 Y313 R316 H324
Binding residue
(residue number reindexed from 1)		M131 N133 I134 N191 R194 Q195 V227 M231 R233 Q234 N235 W253 D254 T265 G266 Y267 L269 Y292 R295 H303
Enzymatic activity
Enzyme Commision number 2.1.1.85: protein-histidine N-methyltransferase.
Gene Ontology
Molecular Function
GO:0018064 protein-L-histidine N-tele-methyltransferase activity
Biological Process
GO:0030047 actin modification

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Molecular Function
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Biological Process
External links
PDB RCSB:6ict, PDBe:6ict, PDBj:6ict
PDBsum6ict
PubMed30785395
UniProtQ86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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