Structure of PDB 6hc3 Chain D Binding Site BS01
Receptor Information
>6hc3 Chain D (length=192) Species:
9606
(Homo sapiens) [
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SSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELP
DSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKA
MTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNL
SDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRT
Ligand information
>6hc3 Chain E (length=22) [
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taacaaaaaatttccaccaaac
Receptor-Ligand Complex Structure
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PDB
6hc3
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Resolution
3.1 Å
Binding residue
(original residue number in PDB)
K51 K52 V54 L58 K62 T77 I81 H137 M143 K147 R157 Y162 Q179 L182 K186 K190 Y211 R232 R233 T234
Binding residue
(residue number reindexed from 1)
K9 K10 V12 L16 K20 T35 I39 H95 M101 K105 R115 Y120 Q137 L140 K144 K148 Y169 R190 R191 T192
Binding affinity
PDBbind-CN
: Kd=13.6nM
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6hc3
,
PDBe:6hc3
,
PDBj:6hc3
PDBsum
6hc3
PubMed
31114891
UniProt
Q00059
|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)
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