Structure of PDB 6f57 Chain D Binding Site BS01

Receptor Information
>6f57 Chain D (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQG
KIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGR
LFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVM
IDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSK
VRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSN
MSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f57 Structural basis for DNMT3A-mediated de novo DNA methylation.
Resolution3.098 Å
Binding residue
(original residue number in PDB)		I715 P718 V763 R836 N838 K841 L883
Binding residue
(residue number reindexed from 1)		I86 P89 V134 R207 N209 K212 L254
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6f57, PDBe:6f57, PDBj:6f57
PDBsum6f57
PubMed29414941
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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