Structure of PDB 6erh Chain D Binding Site BS01

Receptor Information
>6erh Chain D (length=535) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHHHHHHHHHHENLYFQGVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQ
AKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHL
MLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIE
IFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGGITEQQKEGLEIV
KMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLS
IRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKE
DIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMG
NQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVA
FPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALI
DSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPI
QQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6erh XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y-2 F-1 Q0 V2 R3 K126 R242 H243 S244 I245 K265 K273 Y397 R400 A401 N402
Binding residue
(residue number reindexed from 1)		Y15 F16 Q17 V19 R20 K143 R234 H235 S236 I237 K257 K265 Y389 R392 A393 N394
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erh, PDBe:6erh, PDBj:6erh
PDBsum6erh
PubMed30291363
UniProtP13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)

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