Structure of PDB 6brr Chain D Binding Site BS01

Receptor Information
>6brr Chain D (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRH
QGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNP
VMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKF
SKVRTITTASNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDV
SNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6brr Structural basis for DNMT3A-mediated de novo DNA methylation.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		S708 C710 N711 S714 V716 N717 P718 E756 V758 R790 R792 R831 T832 T835 G890 R891
Binding residue
(residue number reindexed from 1)		S81 C83 N84 S87 V89 N90 P91 E129 V131 R163 R165 R204 T205 T208 G263 R264
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6brr, PDBe:6brr, PDBj:6brr
PDBsum6brr
PubMed29414941
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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