Structure of PDB 6b9l Chain D Binding Site BS01
Receptor Information
>6b9l Chain D (length=174) Species:
9606
(Homo sapiens) [
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KEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKK
Ligand information
>6b9l Chain H (length=10) Species:
32644
(unidentified) [
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SAYPDSVPFR
Receptor-Ligand Complex Structure
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PDB
6b9l
Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
Resolution
3.2 Å
Binding residue
(original residue number in PDB)
L54 M55 Q56 N57 Y65 M66 R103 F108 F156 R159 V161 C188 L192
Binding residue
(residue number reindexed from 1)
L28 M29 Q30 N31 Y39 M40 R77 F82 F130 R133 V135 C162 L166
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6b9l
,
PDBe:6b9l
,
PDBj:6b9l
PDBsum
6b9l
PubMed
30110533
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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