Structure of PDB 5zob Chain D Binding Site BS01

Receptor Information

>5zob Chain D (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGR
LDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPG
IFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSA
ITQGKR

Ligand information

>5zob Chain J (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gRRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zob Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 G133 S135 G151 N152 G153 V155 Y161
Binding residue (residue number reindexed from 1)	H37 D115 Y116 G119 S121 G137 N138 G139 V141 Y147

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5zob, PDBe:5zob, PDBj:5zob
PDBsum	5zob
PubMed	30315877
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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