Structure of PDB 5zmq Chain D Binding Site BS01

Receptor Information

>5zmq Chain D (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VKKGETTDGVYRVMTGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKSGRVIGLYGNGVVIKNGSYVSAIT
QGKR

Ligand information

>5zmq Chain I (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cKKR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zmq Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
Resolution	1.987 Å
Binding residue (original residue number in PDB)	H51 Y130 A132 G133 S135 G151 N152 G153 V155 Y161
Binding residue (residue number reindexed from 1)	H35 Y114 A116 G117 S119 G135 N136 G137 V139 Y145

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5zmq, PDBe:5zmq, PDBj:5zmq
PDBsum	5zmq
PubMed	30315877
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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