Structure of PDB 5z3g Chain D Binding Site BS01

Receptor Information
>5z3g Chain D (length=247) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVRAESIVAKTLATSREKERIKRVSILEDKKAKNETQHIASGKDFILKIT
EGLIREKTTYDGKPALLFIVRVRGPLAVNIPNKAFKILSLLRLVETNTGV
FVKLTKNVYPLLKVIAPYVVIGKPSLSSIRSLIQKRGRIIYKGENEAEPH
EIVLNDNNIVEEQLGDHGIICVEDIIHEIATMGESFSVCNFFLQPFKLNR
EVSGFGSLNRLRKIKQREAESRTRQFSNAATAPVIEVDIDSLLAKLN
Ligand information
>5z3g Chain C (length=65) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacu
ugaaauugccuuaaa
......<<<<<.....>>>>>.....<<<<...<<<......>>>..>>>
>..............
Receptor-Ligand Complex Structure
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PDB5z3g Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		E59 L66 R70 R77 H92 I93 A94 S95 K97 K132 R148 G149 L151 V153 V169 T171 R275 G279 F280 K288 R292 F301 S302 N303 A304
Binding residue
(residue number reindexed from 1)		E5 L12 R16 R23 H38 I39 A40 S41 K43 K57 R73 G74 L76 V78 V94 T96 R200 G204 F205 K213 R217 F226 S227 N228 A229
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0042134 rRNA primary transcript binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0022625 cytosolic large ribosomal subunit
GO:0030687 preribosome, large subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z3g, PDBe:5z3g, PDBj:5z3g
PDBsum5z3g
PubMed29557065
UniProtP40693|RLP7_YEAST Ribosome biogenesis protein RLP7 (Gene Name=RLP7)

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