Structure of PDB 5vhc Chain D Binding Site BS01

Receptor Information
>5vhc Chain D (length=799) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDSEYLLQENEPDATLDQQLLEDLQKKKTDLRYIEMQRFREKLPSYGMQK
ELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQP
RRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGI
ILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVVKDLLSYRPDLKVVL
MSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPEYYYE
AIYKERWPGYLRELRQRYSASTVDVVEMMDDEKVDLNLIAALIRYIVLEE
EDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFIIIPLHSLMPTVNQTQV
FKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTM
SAEWVSKANAKQRKGRAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPL
EELCLQIKILRLGGIAHFLSRLMDPPSNEAVLLSIKHLMELNALDKQEEL
TPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG
KEKVADARRKELAKDTKSDHLTVVNAFKGWEKAKQRGFRYEKDYCWEYFL
SSNTLQMLHNMKGQFAEHLLGAGFVSSRNPQDPESNINSDNEKIIKAVIC
AGLYPKVAKIRLNLKMVKVYTKTDGVVAIHPKSVNVEQTEFNYNWLIYHL
KMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIIFQSPA
RIAHLVKELRKELDILLQEKIESPHPVDWKDTKSRDCAVLSAIIDLIKT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5vhc Chain D Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5vhc Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		T239 E337
Binding residue
(residue number reindexed from 1)		T73 E171
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5vhc, PDBe:5vhc, PDBj:5vhc
PDBsum5vhc
PubMed29899445
UniProtQ05B79|DHX36_BOVIN ATP-dependent DNA/RNA helicase DHX36 (Gene Name=DHX36)

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