Structure of PDB 5tb5 Chain D Binding Site BS01

Receptor Information
>5tb5 Chain D (length=146) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKIL
KCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNT
WQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain5tb5 Chain C Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5tb5 Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		L17 M20 S39 Q78 T131
Binding residue
(residue number reindexed from 1)		L13 M16 S35 Q74 T127
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0007601 visual perception
GO:0050953 sensory perception of light stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5tb5, PDBe:5tb5, PDBj:5tb5
PDBsum5tb5
PubMed27791178
UniProtO43924|PDE6D_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Gene Name=PDE6D)

[Back to BioLiP]