Structure of PDB 5ohz Chain D Binding Site BS01

Receptor Information
>5ohz Chain D (length=442) Species: 1122247 (Mycolicibacterium hassiacum DSM 44199) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSFTPTQLAARAAYLLRGNDLGTMTTAAPLLYPHMWSWDAAFVAIGLAPL
SVERAVVELDTLLSAQWRNGMIPHIVFANGVDGYFPGPARWATATLADNA
PRNRLTSGITQPPVHAIAVQRILEHARTRGRSTRAVAEAFLDRRWGDLMR
WHRWLAECRDRNERGRITLYHGWESGMDNSPRWDSAYANVVPGKLPEYQR
ADNVIITDPSQRPSDGEYDRYLWLLEEMKAVRYDDERLPSVMSFQVEDVF
FSAIFSVACQVLAEIGEDYKRPHADVKDLYLWAERFRAGVVETTDQRTGA
ARDFDVLAEKWLVTETAAQFAPLLCGGLPHDRERALLKLLEGPRFCGHPD
LKYGLIPSTSPVSRDFRPREYWRGPVWPVLTWLFSWCFARRGWAERARLL
RQEGLRQASDGSFAEYYEPFTGEPLGSMQQSWTAAAVLDWLG
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain5ohz Chain D Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ohz The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation.
Resolution2.036 Å
Binding residue
(original residue number in PDB)		W40 Y88 D182 R216 Y375
Binding residue
(residue number reindexed from 1)		W36 Y84 D178 R212 Y371
Annotation score2
Enzymatic activity
Enzyme Commision number 3.2.1.208: glucosylglycerate hydrolase.
Gene Ontology
Molecular Function
GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0102547 glucosylglycerate hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ohz, PDBe:5ohz, PDBj:5ohz
PDBsum5ohz
PubMed31316802
UniProtK5BDL0|GGH_MYCHD Glucosylglycerate hydrolase (Gene Name=ggh)

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