Structure of PDB 5n2v Chain D Binding Site BS01

Receptor Information
>5n2v Chain D (length=126) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMEDENILRNAVNLQVLKFHYPEIESIIDIASHVAVYQFDVGSQKWLKTS
IEGTFFLVKDQRARVGYVILNRNSPENLYLFINHPSNVHLVDRYLIHRTE
NQHVVGLWMFDPNDMSRIFNIVKESL
Ligand information
>5n2v Chain F (length=23) Species: 4896 (Schizosaccharomyces pombe) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ILYAGPTFTHSPAASNLPIPTFL
Receptor-Ligand Complex Structure
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PDB5n2v Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H32 Y36 F38 W45 K47 E51 V90 Y93 I95 R97 W107 F109
Binding residue
(residue number reindexed from 1)		H33 Y37 F39 W46 K48 E52 V91 Y94 I96 R98 W108 F110
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0170008 mRNA phosphatase activator activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006397 mRNA processing
GO:0043085 positive regulation of catalytic activity
GO:0110156 mRNA methylguanosine-cap decapping
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0098745 RNA decapping complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n2v, PDBe:5n2v, PDBj:5n2v
PDBsum5n2v
PubMed28533364
UniProtQ9P805|DCP1_SCHPO mRNA-decapping enzyme subunit 1 (Gene Name=dcp1)

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